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Posts Tagged ‘Tasigna’

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TODAY’S NEWS:

Prostate cancer drug treatment (Sanofi) approved on the fast track. But – a warning flag for S-A about possible Lantus/cancer link.

Bayer and OncoMed to co-develop oncology drugs in new agreement.

Novartis‘ blood cancer drug Tasigna gets approval for earlier use with CML.

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SocialRx – pharma social media resources. A page full of goodies, newly updated from us here at Impactiviti. Enjoy!

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Sex pills for women. Count me among the skeptics. And, medical flops of the decade (from Forbes).

JUST FOR FUN

Just where in the world is that South Africa place??

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Impactiviti Daily will not be published next week, as I will be attending the annual Society of Pharmaceutical and Biotech Trainers conference (SPBT) in Orlando.

TODAY’S NEWS:

As the pre-ASCO news heats up, the big headline will be leukemia treatments – specifically, BMS‘ Sprycel and Novartis‘ Gleevec and Tasigna (just inTasigna shown superior to Gleevec in slowing CML: 18-month results). Treatments in this class, by the way, are something near miracle drugs. They’ve totally revolutionized blood cancer treatments. In related news, Novartis’ Afinitor (approved for kidney cancer) meets goals in a trial for pancreatic cancer.

Why should you be interested in a “nanosponge”? Well, there’s this – Scientists have found that a delivery system based on a technique called nanosponge is three to five times more effective at reducing tumor growth than direct injectionmore

Will Amgen‘s new osteoporosis drug Prolia find its true home in oncology treatment? – The company has also applied for FDA approval to market the drug to breast cancer and prostate cancer patients who are undergoing a hormone treatment that weakens their bones. What’s more, the company is conducting tests designed to show that Prolia prevents cancer from spreading to the bones — an indication that could push sales of the drug to as much as $6 billion annually, some analysts predictmore Also – huge sales force push for Prolia.

20% of high school students abuse prescription drugs. Wow – sobering.

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Simulations/Gaming. Live training simulations, digital sims (eLearning) and on-line games – our partner network has the expertise you need.  Contact us (stevew at impactiviti dot com, or phone at 973-947-7429) for recommendations.

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How to reduce e-mail ping-pong. You know all that back-and-forth? Here’s a way to undercut it at the start!

JUST FOR FUN

See-through animals. Ten of them. Amazing.

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Sign up for the Impactiviti Connection twice-monthly e-newsletter (see sample)

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TODAY’S NEWS

Big news on the leukemia front: NovartisTasigna gets priority FDA review for newly-diagnosed patients; and Roche/Genentech‘s Rituxan approved for CLL.

A quarter of new prescriptions go unfilled.

Statins: cardiovascular benefits far outweigh the diabetes risks – Statin drugs raise the risk of diabetes significantly, but the danger appeared puny compared with their cardiovascular benefits, researchers found in a meta-analysismore

Gilead looking to ride a Quad to victory in HIV – Gilead Sciences has gone some way to ensuring that its dominance of the HIV market continues after phase II data from its “Quad” pill presented at the Conference on Retroviruses and Opportunistic Infections showed non-inferiority to its second best-selling drug, Atriplamore

Pharma eMarketing round-up: some great links and a big, thought-provoking question.

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Product launch training – If you’ve got new product launches in the plans, we have top vendor/providers to help with therapeutic area training, product modules, animations, meetings and events – just let us know. Contact us (stevew at impactiviti dot com, or phone at 973-947-7429) for recommendations.

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Even Me-Too Drugs get the blues

JUST FOR FUN

I don’t recommend you try this at home! But what happens when an iMac meets a house fire? The result is…surprising, to say the least!

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TODAY’S NEWS

Novartis’ “son of Glivec” (Tasigna) carrying on the family tradition – Novartis has reported result of Tasigna Phase III clinical trial. In the study, Tasigna (nilotinib) demonstrated greater efficacy over Glivec (imatinib) in the treatment of adult patients with newly diagnosed Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) in chronic phasemore

Need to count calories as part of your diabetes regimen? Yep – there’s an app for that. Developed by Sanofi-Aventis with InTouch Solutions.

Worried about prostate cancer? There may be an app for that – coffee!

Quick overview of a growing trend – personalized medicine.

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Territory Management. Need to train your sales reps in better territory management (and selling skills)? We have vendor/providers for that, in the Impactiviti network.  Contact us (stevew at impactiviti dot com, or phone at 973-947-7429) for recommendations.

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Updated again: Jon Richman’s excellent Dose of Digital Pharma and Healthcare Social Media Wiki. If you want to know what’s going in the world of social media in pharma, here’s your starting point.

JUST FOR FUN

Start your day off with a smile. Something about this event at a hockey rink is very heartwarming…

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Subscribe to the Impactiviti blog via e-mail (which will bring you Impactiviti Daily – a brief of the day’s top pharma news)

Sign up for the Impactiviti Connection twice-monthly e-newsletter (see sample)

Connect with Steve Woodruff

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Glaxo buying Reliant – GlaxoSmithKline Plc has agreed to buy privately held heart drug specialist Reliant Pharmaceuticals for $1.65 billion in cash, in a move to boost its flagging drug sales in the United States…more

J&J says good-bye to $440 mil – Johnson & Johnson said on Thursday its fourth-quarter results would include a special after-tax, noncash charge of $440 million from a write-down related to a decline in sales of acute heart failure drug Natrecor…more

Fountain of youth? – Scientists at Sirtris Pharmaceuticals Inc. say they have created a drug that mimics the ingredient in red wine linked to longevity and the cell structures that power endurance athletes like cycling champion Lance Armstrong. The new molecule is 1,000 times more potent than the wine derivative, resveratrol, and could lead to solutions for diseases of aging, including cancer and diabetes, according to authors of a study in today’s issue of the journal Nature…more

Abbott‘s Xience stent showing good side effect profile and efficacy…gets FDA panel green light – Abbott Laboratories Inc  won a U.S. advisory panel’s support on Thursday for an experimental drug-coated stent for heart patients. A committee of advisers to the Food and Drug Administration voted 9-1 to recommend approval of the device, called Xience. The FDA usually follows panel recommendations…more

On the Oncology front…

Novartis gets EU approval for Tasigna – Novartis AG (NVS) Wednesday said that Tasigna, a potential follow-up to Gleevec, the Swiss drugmaker’s second best-selling drug, won European Union approval for the treatment of a certain form of leukemia. Novartis, based in Basel, said Tasigna is a new targeted cancer drug for patients with a form of the life-threatening blood cancer chronic myeloid leukemia, who are resistant or intolerant to treatment with Gleevec. Novartis expects Tasigna to eventually replace Gleevec and plans to test its efficacy and safety in patients who haven’t yet been treated with Gleevec…more

Celgene‘s Revlimid combined with dexamethasone effective for multiple myeloma – A combination drug regimen that includes a derivative of thalidomide extended survival, as well as the time it took for the disease to reappear, in patients with multiple myeloma…more

Freeze tumors, reduce pain – Freezing tumors may help relieve the extreme pain of cancer that has spread to the bone, which is often untouched by narcotics or radiation, U.S. researchers said on Tuesday. This freezing process, called cryoablation, is often used to destroy kidney, prostate and other tumors, but researchers at the Mayo Clinic in Rochester, Minnesota, found it eased cancer pain in 80 percent of patients in a small study, and the effect lasted for up to six months…more

It’s not drugs, but it’s fascinating – Vivek Rangnekar, a University of Kentucky College of Medicine professor of radiation medicine and a team of researchers say they have found a tumor-suppressor gene called “Par-4” in the prostate. The researchers discovered that the Par-4 gene kills cancer cells, even highly aggressive types, but not normal cells, according to a study published in the journal Cancer Research and funded by grants from the National Institutes of Health. Rangnekar’s study found that mice born with this gene do not develop tumors. They grow normally, have no defects and actually live a few months longer than the control animals…more

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A huge week for news, especially on the cardiovascular front:

Prasugrel, the Lilly/Daiichi-Sankyo blood thinner, was the biggest headline grabber. This potential blockbuster came in with mixed results – good efficacy, but troubling side effects with some patients. Meanwhile, a bit further back in the pipeline, Schering-Plough‘s experimental anti-clotting med continues to look very promising.

Speaking of Schering and blood clots, it appears that smaller doses of Integrilin are just as effective as the more traditional (higher) dosing.

AstraZeneca‘s Crestor gets a new indication, for treatment of artery-clogging. However, it did not show efficacy for heart failure patients.

Bayer launches a huge study for its promising blood clot drug rivaroxaban.

Why did Pfizer‘s torcetrapib fail? Some reasons may be surfacing.

Surprise – diarrhea drug effective for Hepatitis C?? Surprise, surprise – sleep drug awakens comatose patients.

Novartis Tasigna moving forward. Galvus moving backward.

Court case: Red Cross 1, J&J 0. But this ain’t over yet…

Cephalon: Loss posted, and Corporate Integrity Agreement signed.

BMS‘s oncology drug Sprycel – new labeling for CML.

J&J/Schering-Plough experimental arthritis drug meets goals in study.

JUST IN: Merck to pay huge amount to settle bulk of Vioxx claims?

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