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Archive for the ‘Genzyme’ Category

Pay-for-Fail

Finally, after a long (and at times contentious) set of turns around the dance floor, Sanofi and Genzyme have agreed to merge.

The big winner? Henri Termeer, who presided over the decline and now sale of Genzyme. A nice $160 million reward for…..what? Certainly not success.

I’m an unabashed capitalist. But this is yet another in a long string of Board-of-Director-abdications-of-responsibility that give pharmaceutical companies (and plenty of companies in other industries) a bad name.

Nobody should get a package anything like this. And, if a top leader does earn (note the word: EARN) a rich payout at the end of his/her tenure, it should be tied to metrics of growth that have clearly rewarded the shareholders, employees, and patients first. If you run a company into the ground, you should be run out on a rail, not driven out in a stretch limo with a bursting bank account.

It’s enough to make you need an anti-emetic.

Yes, the pharmaceutical industry has a P.R. problem. But this type of fiscal irresponsibility is a self-inflicted wound. I can hardly blame a CEO for taking the money and running. But shareholders need to revolt against directors who approve packages like this, and put them out to pasture ASAP. It’s an embarrassment and a travesty.

Pay-for-Performance – let’s start right at the top and then work our way down, shall we??

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TODAY’S NEWS:

Very big news for Vertex75% of hepatitis C patients never treated before achieved a viral cure after receiving a 12-week course of the company’s experimental drug telaprevir plus the current standard of care, according to results from a phase III studymore

Genzyme’s Pompe remedy approved by FDA; meanwhile, more detail on their consent decree.

More on alleged Wyeth tactics to promote Rapamune off-label. If true, yuck! Gold-in Rule at work.

Connecticut passes new pharma ethics code.

Part 2 of my interview over at MessagingLab blog (by Karl Schmieder): Pharma, Social Media, and the FDA.

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Social Media in Pharma stuff today: An “Ultimate Guide to Facebook“, from our friends over at Pixels and Pills. And, reporting adverse events on social media. More? Sure – comparing how pharma companies are using social media currently (from @healthcarengage). Even more? OK, you asked for it – Social Media and Celebrities in pharma (from John Mack’s blog)

JUST FOR FUN

Examples of Lightning Photography. Stunningly beautiful.

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TODAY’S NEWS:

Watson gets FDA approval to start shipping generic Valtrex.

Novartis oral MS drug – FDA extends review another 3 months – Novartis will have to wait a bit longer in its bid to get the first oral treatment for multiple sclerosis on the market after regulators in the USA put back a review of Gilenia. The US Food and Drug Administration has extended by three months, to September, its review period for Gilenia (fingolimod), previously known as FTY720more

Genzyme: Big fine, big changes to get manufacturing back under control.

Another day, another whistleblower suit comes to light. This time, Wyeth and Rapamune promotion for unapproved uses.

Layoffs at Quintiles.

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The Three “I’s” of Tomorrow’s Successful Company. An important perspective from Dennis Urbaniak (VP U.S. Diabetes, Sanofi-Aventis). Titles, Budgets, and Staff are out – Ideas, Initiative, and Inspiration are in.

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50 Beautiful Examples of Architecture Photography.———-

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TODAY’S NEWS

Novartis announces a major US reorganization, including re-aligned business units, and cuts. Ouch.

Crystal ball – what will be the biggest drug(s) in 2014? Here are some educated guesses.

Use Remicade early in Crohn’s, the results say – “The results are pretty definitive,” Sandborn told MedPage Today. “Most patients should receive infliximab combination therapy as the most effective strategy.“…more

Genzyme‘s Campath for MS:  preliminary data look quite promising – Data presented on Wednesday at the annual meeting of the American Academy of Neurology showed that after four years, 71 percent of patients had no relapse or worsening of disability. That compares with 35 percent for patients taking Rebif, a rival drug made by EMD Serono, an affiliate of Germany’s Merck KGaA and Pfizer Incmore

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I’m Restless – how about you?

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Come out of your shell. Cool photos – just trust me and look.

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TODAY’S NEWS

What about those bone fracture risks with biophosphonate drugs? The jury is still out – A new study gives reassuring news about the safety of Fosamax and Reclast, bone-building drugs taken by millions of American women. It found that long-term use does not significantly raise the risk of a rare type of fracture near the hipmore

Monthly hepatitis C treatment looking promising – Human Genome Sciences Inc. said Wednesday a midstage study of the potential hepatitis C treatment Zalbin showed a monthly dose of the drug candidate could be as effective as a weekly dose of the standard treatment. The Rockville, Md., company said interim results from the study support evaluation of the monthly dose in a bigger, late-stage trial. The midstage study was conducted by Novartis, which is developing the drug with Human Genome Sciences. It combined the drug with ribavirin in 391 patients with forms of chronic hepatitis Cmore

Massive Multaq Mess Might Mean Major Meltdown – The scale of Sanofi-Aventis (SNY)’s Multaq mess is starting to become apparent: The heart drug, hailed by the company as a €1 billion-plus blockbuster prior to its launch, may miss Wall Street sales estimates by as much as €1.3 billion, according to analysts at Jefferies International. When investors wake up and downgrade their expectations for the atrial fibrillation drug, Sanofi’s stock may suffer, they say…more

Genzyme - feeling fines.

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Another reason to like Gilead Sciences (besides the fact that they have the best logo in the industry) – they actually have a rational pay plan for their top executive. What would it look like if pharma upper executive pay were based on annual performance for these measures: Profitability ratio (earnings vs. # of employees – something Gilead excels at, by the way); company share increase over a 3-year running average; and regulatory compliance? We might then see real pay-for-performance!

JUST FOR FUN

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TODAY’S NEWS

Combo pills for high cholesterol: no better than higher doses of single drug? Interesting study results.

Should we really be doing all those PSA tests for prostate cancer? Maybe not.

Shire‘s Gaucher drug on the fast track, due to Genzyme manufacturing problems.

A NY Times interview with Deborah Dunsire, CEO of Millennium – good focus on leadership development.

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FDA silence about social media guidance “a problem,” according to a Pfizer exec. Agreed.

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Here’s a lightning bolt you definitely would not want to see up-close and personal. Wow!

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TODAY’S NEWS

Takeda to move forward with new alogliptin study – Takeda Pharmaceutical Co says it is all set to start an additional clinical trial demanded by US regulators on alogliptin, its investigational type 2 diabetes drug. The Japanese drugmaker noted that the US Food and Drug Administration has agreed to the study design for a cardiovascular outcomes trial, titled EXAMINE for alogliptin, a selective dipeptidyl peptidase IV inhibitor (DPP-4) inhibitor also known as SYR-322. The study will involve 5,400 type 2 diabetes patients at around 1,000 facilities in the USA, Europe and Asiamore

Genzyme leukemia drug study: hard to interpret - “The lack of a randomized study combined with the heterogeneous patient population regarding AML prognostic factors makes interpretation of the study results difficult.” Food and Drug Administration staff said in an analysis prepared for the panel, which meets Tuesdaymore

Smoker’s lung treatment: coming soon from Forest and Nycomed? – An experimental once-daily tablet from Nycomed and Forest Laboratories improves lung function in people with “smoker’s lung” and may be a useful add-on to conventional inhaled drugs, experts said on Friday. Privately owned Swiss drugmaker Nycomed, which is working towards a multibillion-dollar flotation, hopes Daxas will reach the market in 2010 and believes it has blockbuster potentialmore

Pharmas that got hurt by debt shenanigans, including BMS and Teva. And, a rash of drug heists.

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Younger folks just don’t want to take their cholesterol meds.

JUST FOR FUN

A Danger sign you don’t want to see…
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